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Patient Education – Tirzepatide

The information contained is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor or pharmacist before taking any prescription or over-the-counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor or pharmacist can provide you with advice on what is safe and effective for you.

Tirzepatide injection is used to treat type 2 diabetes, and promote weight loss. It is used together with diet and exercise to help control your blood sugar. Tirzepatide is a glucagon-like peptide-1 (GLP-1) receptor agonist.

This medicine is also used together with diet and exercise to help lose weight and keep the weight off in patients with obesity caused by certain conditions. Along with its needed effects, a medicine may cause some unwanted effects.

Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur:

More common

  • Stomach pain

Less common

  • Difficulty in breathing or swallowing
  • Fast heartbeat
  • Gaseous stomach pain
  • Heartburn
  • Recurrent fever
  • Skin itching, rash, or redness
  • Stomach fullness
  • Swelling of the face, throat, or tongue
  • Vomiting
  • Yellow eyes or skin

Incidence not known

  • Anxiety
  • Bloating
  • Blurred vision
  • Change in vision
  • Chest tightness
  • Chills
  • Cold sweats
  • Coma
  • Confusion
  • Constipation
  • Cool, pale skin
  • Cough
  • Darkened urine
  • Depression
  • Dizziness
  • Fast heartbeat
  • Fever
  • Increased hunger
  • Indigestion
  • Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • Loss of appetite
  • Nausea
  • Nervousness
  • Nightmares
  • Pains in the stomach, side, or abdomen, possibly radiating to the back
  • Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • Seizures
  • Shakiness
  • Slurred speech
  • Unusual tiredness or weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. 

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Acid or sour stomach
  • Belching
  • Constipation
  • Diarrhea
  • Stomach discomfort or upset

Less common

  • Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. 

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.